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Certain Factors including Fluoride which affect Magnesium Calcinosis in the Dog and Rat¹

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

The studies herein reported confirm in part observations previously made and indicate further that certain interrelationships between Mg, Ca, P and F^- were involved in the low Mg induced calcinosis. A balance of these elements was essential for its prevention and control. Dietary F^- greatly reduces, or largely prevents calcinosis in the dog, whereas the rat is less likely to show a reduction of excessive calcification of low Mg-induced calcinosis. The evidence at this time suggests a species differences. Minimal prevention level in the dog was 25 ppm F^-. This effect was independent of feed intake. From the results in the response of calcinosis in dogs by fluoride treatment during magnesium depletion and 25-day repletion, it appeared that fluoride prevented the initiation of the calcification of soft tissues but it had no effect on the preformed calcified lesions during the course of 25-day repletion period.

Manuscript received 4 December 1964.