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Some Aspects of Glucose Metabolism of Chromium-deficient Rats Raised in a Strictly Controlled Environment

Division of Biochemistry, Walter Reed Army Institute of Research, Washington, D. C. and Brattleboro Retreat, Brattleboro, Vermont

Intravenous glucose tolerance and glucose oxidation in vitro was measured in chromium-deficient rats raised under conditions which allowed strict control of trace element contaminations. A severe impairment of glucose removal rates was observed in all animals. Subsequent chromium supplementation resulted in significant increases of rates toward normal values. Oxidation of glucose in vitro by adipose tissue of chromium-deficient rats was lower than that of supplemented animals, both in the presence and absence of insulin. These results indicate a more severe degree of chromium deficiency than that observed in rats raised in an ordinary environment.

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				W. H. Glinsmann, F. J. Feldman, and W. Mertz Plasma Chromium after Glucose Administration Science, May 27, 1966; 152(3726): 1243 - 1245. [Abstract] [PDF]