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Journal of Nutrition Vol. 85 No. 4 April 1965, pp. 400-406
Copyright © 1965 by American Society for Nutrition
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Relationship between Cholesterol and Vitamin a Metabolism in Rats Fed at Different Levels of Vitamin A1

Shirley V. Bring, Cecelia A. Ricard2 and Mary V. Zaehringer

Home Economics Research, College of Agriculture, University of Idaho, Moscow, Idaho

The relationship between cholesterol and vitamin A metabolism was studied in 3 replications using a total of 225 weanling male rats. Following vitamin A depletion, each animal was assigned at random to an experimental group, receiving one treatment from each of the following 3 variables: 0.0 or 0.5% cholesterol mixed in the basal purified diet; 10, 150 or 1000 IU vitamin A acetate daily administered orally; and fed 7, 18 or 28 days. Feed was available approximately 18 hours daily. Serums were assayed for carotene, vitamin A and free and total cholesterol, and livers, for vitamin A, free and total cholesterol, total fat and moisture. Increasing the dietary vitamin A decreased the serum and liver total cholesterol concentrations when cholesterol was fed. The rats given 10 IU vitamin A daily had significantly higher (P < 0.01) liver total cholesterol values than those given either 150 or 1000 IU. Cholesterolfed rats given 10 IU also had significantly higher (P < 0.01) mean serum cholesterol values than those given 1000 IU. Dietary cholesterol significantly lowered (P < 0.05) mean liver vitamin A concentrations on a dry weight basis. Liver vitamin A and free cholesterol were found to be positively correlated (P < 0.01) on either a percentage or per liver basis.

1 Published with the approval of the Director of the Idaho Agricultural Experiment Station as Research Paper no. 628. This study was supported in part by funds from Regional Projects W-4 and W-44 of the Western Agricultural Experiment Stations.

2 Present address: Box 79, Uniontown, Washington.

Manuscript received 10 August 1964.




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