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Zinc-65 Absorption and Turnover in Rats

I. A Procedure to Determine Zinc-65 Absorption and the Antagonistic Effect of Calcium in a Practical Diet^1,2,

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

Zinc-65 as chloride or glycine complex was administered to growing rats receiving a practical diet in 6 experiments. A rapid fecal excretion of Zn⁶⁵ occurred following administration via feed or gavage. Increased dietary calcium significantly increased (P < 0.01) the initial rate of Zn⁶⁵ loss following oral administration and consistently and significantly decreased the percentage remaining in the body longer than 2 days. Conversely, body loss of injected Zn⁶⁵ decreased significantly (P < 0.01) with increased calcium. Comparison of retention curves at 100 to 250 hours post-administration for injected and dietary or gavage-administered Zn⁶⁵ and their extrapolation to zero time allowed the determination of the percentage of radiozinc absorbed. Calcium significantly decreased (P < 0.01) the percentage of Zn⁶⁵ absorption and increased the biological half-life (decreased turnover) of Zn⁶⁵ beyond 100 hours post-administration. Calcium did not affect body weight. The results are explained by a decreased absorption of stable and radiozinc with increased dietary calcium. Calcium also significantly increased (P < 0.01) carcass Zn⁶⁵ in the femur and decreased it in liver, kidney and muscle at 28 days post-administration.

² Roberts, H. F., and W. G. Hoekstra, unpublished data.

Manuscript received 21 October 1964.

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