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Effect of Reducing Agents on Copper Deficiency in the Chick^1,2,

North Carolina State, The University of North Carolina at Raleigh, North Carolina

The effect of additions of reducing agents to copper-deficient chick diets was investigated. Ascorbic acid and isoascorbic acid, at 0.1%, and dimercaptopropanol (BAL) at 0.025% of the diet decreased growth and either decreased the elastin content of the aorta or increased mortality in those groups of chicks receiving a copper-deficient, but not a copper-supplemented diet. Diphenylphenylenediamine (DPPD) had no such effect. Ascorbic acid had no effect on zinc or iron deficiency. Dietary ascorbic acid reduced the uptake of Cu⁶⁴ by the liver whether the isotope was given orally or intraperitoneally.

² Supported in part by Public Health Service Research Grant no. A 5651 from the National Institutes of Health and by a grant from the Moorman Manufacturing Company, Quincy, Illinois.

Manuscript received 26 October 1964.

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