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Interrelation of Vitamin B₆ and Sex on Response of Rats to Hypercholesterolemic Diets¹

Division of Nutrition, Bureau of Scientific Research, Food and Drug Administration, Washington, D. C.

When weanling rats were fed purified diets with added cholesterol and cholic acid for 20 weeks, the blood cholesterol levels of females were two to three times higher than those of males. This effect was greatest when the diet contained a severely hypercholesterolemic fat (coconut oil), and least with cottonseed oil; lard was intermediate. Intermittent vitamin B₆ deficiency eliminated the sex difference in blood cholesterol in rats fed the hypercholesterolemic diets; the values for males increased, whereas the values for females decreased to a point where the sex difference was not significant. Coconut oil in the diet, especially combined with a vitamin B₆ deficiency, caused marked liver cirrhosis, enlarged adrenals, kidney damage and nodules and hyperplasia in the stomach, as well as a pronounced increase in sudanophilic lesions in the aorta.

Manuscript received 21 October 1964.