Journal of Nutrition

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Journal of Nutrition Vol. 85 No. 2 February 1965, pp. 150-158
Copyright © 1965 by American Society for Nutrition
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The Absence of Thyroid Hormones in a Growth Factor of Duodenal Powder1

C. J. Ackerman

Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg, Virginia

Three fractions prepared from the acid-insoluble residue after acid hydrolysis of duodenal powder were effective in reinstating growth of growth-arrested, sulfaguanidine-fed rats. One fraction was studied more extensively than the others to determine whether the growth response to this fraction was due to thyroxine or triiodothyronine. The stability of this fraction to acid hydrolysis, its insolubility in acid, its behavior on paper chromatograms and its failure to react with ninhydrin contrasted with the behavior of thyroxine or triiodothyronine. It was therefore concluded that duodenal powder contains an unidentified substance effective in reinstating growth of growth-arrested, goitrogen-fed rats.

1 Supported in part by a grant, G13165, from the National Science Foundation, Washington, D.C.

Manuscript received 6 August 1964.




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