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Electrophoretic Study of the Effects of Changes in Dietary Protein Concentration and of DL-Ethionine on the Soluble Proteins of Rat Liver

Departments of Biochemistry and Pharmacology, State University of New York, College of Medicine, Syracuse, New York

Measurements, by means of electrophoresis, of the concentrations of soluble proteins in rat liver indicate that the concentrations of these materials vary with the protein concentration of the diet, but the change in concentration is not the same for all liver proteins. One group of proteins of relatively low mobility was observed in the same concentration in the livers of rats receiving either a high protein diet or a low protein diet. These proteins occurred in the mitochondria-plus-microsomes fraction and in the cell sap. The proteins which did change in concentration had greater electrophoretic mobility than the above group. They were derived from the mitochondria-plus-microsomes and from the nuclei. The cell sap contained proteins of similar mobilities but these proteins did not change in concentration as the dietary protein concentration changed. The effect of feeding DL-ethionine on the concentrations of soluble liver proteins was qualitatively very similar to the effect produced by feeding a low protein diet.

² Student Research Fellow, National Science Foundation, Summer, 1957 and 1958.

Manuscript received 29 June 1964.