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Journal of Nutrition Vol. 84 No. 3 November 1964, pp. 259-264
Copyright © 1964 by American Society for Nutrition
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Effect of Dietary Vitamin K on the Nutritional Status of the Rhesus Monkey1

Roberta Bleiler Hill, Harold E. Schendel2, P. B. Rama Rao3 and B. Connor Johnson

Department of Animal Science, University of Illinois, Urbana, Illinois

As a result of dietary vitamin K deficiency, male Macaca mulatta monkeys had prolonged prothrombin times which reversed spontaneously or could be decreased sharply by the administration of small quantities of vitamin K4. This pattern of prolongation and spontaneous reversal was also observed when neomycin sulfate and oxytetracycline were administered. The feeding of irradiated beef diets caused prolongation of the prothrombin time of only one pre-adolescent monkey, although the irradiated beef diets did not contain sufficient vitamin K to maintain rats, even when coprophagy was permitted.

1 These studies were supported in part under contract no. DA-49-007 MD 544 with the Office of the Surgeon General, Department of the Army. The opinions expressed in this publication are those of the authors and not necessarily those of the Department of the Army.

2 Present address: Winthrop College, The South Carolina College for Women, Rock Hill, South Carolina.

3 Present address: Department of Biochemistry, Indian Institute of Science, Bangalore 12, India.

Manuscript received 29 June 1964.




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