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Utilization of Co⁵⁸-labeled Vitamin B₁₂ by Biotin-deficient Rats

Istituto Chimica Biologica, Università di Bologna, Bologna, Italy

The metabolic pattern of vitamin B₁₂ was studied in biotin-deficient rats. The livers of biotin-deficient rats had a significantly higher vitamin B₁₂ content than those the biotin-treated animals. Absorption and excretion of orally administered Co⁵⁸-vitamin B₁₂ were not impaired in biotin-deficient rats, whereas the uptake of radioactivity by major organs was significantly higher. No difference in urine and fecal radioactivity was noted in biotin-deficient rats when Co⁵⁸-vitamin B₁₂ was administered by injection. In these animals the retention of the radiovitamin by the organs was noticeably increased.