QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Marchetti, M. Articles by Testoni, S. Search for Related Content PubMed PubMed Citation Articles by Marchetti, M. Articles by Testoni, S.

Relationships between Biotin and Vitamin B₁₂

Istituto Chimica Biologica, Università di Bologna, Bologna, Italy

Interrelationships between biotin and vitamin B₁₂ were studied. Data indicate that vitamin B₁₂ administration to rats receiving a biotin-free diet exerts a favorable effect on the growth rate and on the delay of the deficiency symptoms in these experimental conditions. Vitamin B₁₂ appears also to have an effect on transcarbamylase activities analogous to biotin, possibly due to an increased intestinal synthesis of biotin and tissue storage. In addition, biotin administration influences methylation examined in the rat in vivo (urinary elimination of N-methylnicotinamide) and in vitro (betainehomocysteine transmethylase) as does vitamin B₁₂ although to a lesser extent. The significance of the interrelationship between vitamins is discussed.