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Journal of Nutrition Vol. 84 No. 2 October 1964, pp. 97-99
Copyright © 1964 by American Society for Nutrition
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Dietary Production of Parathyroid Cysts1

Hans Selye, Manuel Rojo Ortega and Beatriz Tuchweber

Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada

Dietary supplements of dihydrotachysterol (DHT) and calcium acetate transform the parathyroids of the rat into sponge-like cystic organs. This lesion presumably represents "retention cyst" formation. It is tentatively ascribed to a selective blockade of the discharge of parathyroid secretion into the blood, without suppression of its formation within the gland. The advantages of the nutritional technique for the production of parathyroid cysts are discussed.

1 This work was supported by the Canadian Arthritis and Rheumatism Society and the Medical Research Council of Canada.

Manuscript received 23 April 1964.




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