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Effect of Dietary -Tocopherol on Protein Metabolism in Vitamin A-deficient Rats¹

Columbia University, Institute of Nutrition Sciences, School of Public Health and Administrative Medicine, New York, New York

Rats maintained with a vitamin A-deficient diet were fed at 2 levels of -tocopherol. Control animals were pair-fed. Higher dietary -tocopherol caused an increase in the liver stores of vitamin A in the control animals. Vitamin A deficiency increased liver concentration of -tocopherol and lowered serum albumin but increased globulins. In vitro incorporation of C¹⁴-amino acids into diaphragm protein was significantly higher in the tissue of vitamin A-deficient rats fed at the lower -tocopherol intake than in pair-fed controls. In contrast, the incorporation of C¹⁴-amino acids into protein from diaphragm of vitamin A-deficient rats receiving the higher -tocopherol intake was significantly lower than that of pair-fed controls. These changes in protein metabolism may be explained through the effect of vitamin A and E on membrane properties.

² Whitehall Fellow.

³ Williams-Waterman Fellow.

Manuscript received 23 May 1964.

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