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Effects of Chlortetracycline and Isoniazid on Body Weight Gain and Intestinal Urea Hydrolysis of Rats¹

Department of Pharmacology, The University of Chicago, Chicago, Illinois

Results are presented from 4 experiments using 144 weanling male Sprague-Dawley rats fed either a casein-sucrose basal diet or the USP XIV assay diet (fortified with vitamin A), each supplemented with chlortetracycline (100 ppm) and isoniazid (100 ppm), alone and in combination, for a 4-week experimental period. Chlortetracycline with or without isoniazid resulted in markedly increased weight gains, improved efficiency of feed utilization, and lowered intestinal urea hydrolysis when added to the lower quality casein-starch diet. Isoniazid, and antituberculosis agent, was generally ineffective in promoting growth or reducing ureolytic activity when added alone or in combination with chlortetracycline to either diet. Significantly increased growth was observed in one experiment with the casein-sucrose diet when isoniazid was the only additive fed. Results of a fifth experiment with 50 rats fed the USP XIV diet fortified with vitamin A and supplemented with graded amounts of isoniazid (zero to 400 ppm) indicated that 100 ppm was the most suitable concentration tested and that the failure of isoniazid to significantly stimulate growth with this diet was not due to the concentration of the additive used. In general, increase in weight gain due to additives appeared dependent on overall growth rate and nutritional adequacy of the diet.

² Public Health Service Postdoctoral Fellow.

Manuscript received 26 February 1964.