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Biochemical Changes in Progressive Muscular Dystrophy

II. Phosphorus Metabolism in Normal, Nutritional and Hereditary Dystrophic Muscles, Livers and Brains of Animals¹

Departments of Biochemistry, Faculty of Medicine, Laval University, Quebec, Canada and Institute of Post-Graduate Medical Education and Research, Chandigarh, Punjab, India

The distribution pattern of total phosphorus (TP), total inorganic phosphorus (TPi), total acid-soluble phosphorus (TASP), total acid-insoluble phosphorus (TAIP), adenosine triphosphatase, and creatine in the muscle, liver and brain of experimental animals with nutritional (vitamin E) and hereditary dystrophy was studied. ATP and creatine phosphate concentration was greatly reduced in the muscle of dystrophic animals. In contrast, ATPase activity in this tissue increased considerably; in the liver, ATP decreased but the concentration of creatine increased markedly. In the brain of these dystrophic animals, these concentrations did not undergo any significant changes. TP, TPi, TASP and TAIP also increased to various degrees in the muscles of these dystrophic animals, depending upon the severity of the disease and also on the origin of the disease, namely, whether the animal had nutritional or hereditary dystrophy. In the liver of the dystrophic rabbit, TP, TPi, TASP and TAIP showed considerable increases in concentration; on the other hand, in the liver of dystrophic mice, TP, TASP and TAIP decreased and TPi increased. In the brain of rabbits with nutritional dystrophy, the concentration of these was also elevated, but to a much lesser extent; whereas in the brain of severely affected mice, TP and TAIP showed considerable increases with no significant change in TPi and TASP.

Manuscript received 21 February 1964.

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