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Biochemistry Department, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Pyridoxine deficiency in the rat resulted in a consistent decrease in incorporation of L-valine-1-C14 into proteins of liver, spleen and serum and into subcellular fractions of liver and spleen. Rate of incorporation was increased by administration of pyridoxine shortly before injection of labeled valine. Disappearance of labeled valine from these proteins was not affected in the deficient animals.
Manuscript received 13 November 1963.