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Journal of Nutrition Vol. 82 No. 4 April 1964, pp. 483-488
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Effect of Pyridoxine Deficiency upon Valine Incorporation into Tissue Proteins of the Rat1

Anthony C. Trakatellis and A. E. Axelrod

Biochemistry Department, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Pyridoxine deficiency in the rat resulted in a consistent decrease in incorporation of L-valine-1-C14 into proteins of liver, spleen and serum and into subcellular fractions of liver and spleen. Rate of incorporation was increased by administration of pyridoxine shortly before injection of labeled valine. Disappearance of labeled valine from these proteins was not affected in the deficient animals.


1 This study was aided by U. S. Public Health Service research grant A-727 from the National Institute of Arthritis and Metabolic Diseases, and by the office of Naval Research under Contract 1833(00), NR 101-412.

Manuscript received 13 November 1963.





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