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Chemical Pathology of Acute Amino Acid Deficiencies

VI. Influence of Fat Intake on the Morphologic and Biochemical Changes in Young Rats Force-Fed a Threonine-Devoid Diet¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Young Sprague-Dawley rats were force-fed for 3 days a purified diet devoid of threonine and containing 0.6, 5, or 25% corn oil. All animals developed fatty liver with a periportal distribution, increased hepatic glycogen, and atrophy of the pancreas, submaxillary gland, stomach, spleen and thymus. The results indicate that a decrease in dietary fat intake from 5 to 0.6% corn oil does not alter the pathologic changes due to the deficient diet. An increase in dietary fat intake from 5 to 25% corn oil did not protect against the pathologic changes, but actually accentuated some of the changes due to the deficient diet.

Manuscript received 2 August 1963.