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Journal of Nutrition Vol. 82 No. 2 February 1964, pp. 263-268
Copyright © 1964 by American Society for Nutrition
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Effect of Vitamin A and Vitamin A Acid on Cerebrospinal Fluid Pressure and Blood and Liver Vitamin A Concentrations in the Pig1,2,

E. C. Nelson3, B. A. Dehority, H. S. Teague, A. P. Grifo, Jr. and V. L. Sanger4

Department of Animal Science, Ohio Agricultural Experiment Station, Wooster, Ohio

Thirty-six pigs, weaned at 3 weeks of age, were depleted until their blood plasma vitamin A concentrations had decreased to less than 12 µg/100 ml. They were then supplemented for 75 ± 1 days with vitamin A or vitamin A acid, or both. Blood plasma vitamin A increased with vitamin A intake but decreased and was unrelated to any level of vitamin A acid fed. Liver vitamin A increased with vitamin A and vitamin A acid intake although values for the pigs fed vitamin A acid were low. In addition, those pigs fed a combination of vitamin A and vitamin A acid had considerably higher liver vitamin A concentrations than those pigs fed vitamin A alone, indicating that vitamin A acid had a sparing effect on liver vitamin A in the pig. No vitamin A acid could be detected in the plasma or liver. A similar decrease in cerebrospinal fluid pressure occurred with an increase in vitamin A or vitamin A acid intake, suggesting that vitamin A acid was effective in meeting this physiological requirement. Cerebrospinal fluid pressure proved to be an adequate criterion in measuring the vitamin A status of the pig when fed either vitamin A or vitamin A acid.

1 Approved for publication as Journal Article no. 77-63 by the Associate Director of the Ohio Agricultural Experiment Station. The data were taken from a thesis submitted by the senior author in partial fulfillment of the requirement for the degree Doctor of Philosophy.

2 Presented in part at the annual meeting of the American Institute of Nutrition, Atlantic City, New Jersey, 1962. Federation Proc., 21: 474 (abstract).

3 Present address: Department of Biochemistry, Oklahoma State University, Stillwater, Oklahoma.

4 Department of Veterinary Science.

Manuscript received 5 September 1963.




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