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Journal of Nutrition Vol. 82 No. 2 February 1964, pp. 209-216
Copyright © 1964 by American Society for Nutrition
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Effects of Dietary Supplements on Young Rats Fed High Levels of Zinc1

Aden C. Magee and Sandra Spahr

School of Home Economics, University of North Carolina, Greensboro, North Carolina

The effects of several dietary supplements on growth and mineral metabolism of young rats fed high levels of zinc were observed in a series of experiments. Soybean meal offered some protection against subnormal growth, but with a level of 0.75% of zinc, this protection was not as good as that obtained with either liver or distiller's dried solubles. The addition of 20% of distiller's dried solubles to a diet containing 0.75% of zinc completely prevented the marked decreases in weight gain, hemoglobin level and liver copper associated with zinc toxicity. Results of several experiments suggest that dietary protein per se is not the primary factor involved in the subnormal growth associated with zinc toxicosis that is being supplied by the addition of liver or distiller's dried solubles. Results of this study indicate that a high level of protein may accentuate, rather than reduce, the severity of zinc toxicity in rats under certain conditions. This observation does not agree with a previous report by other investigators.


1 Contribution from the Home Economics Department, North Carolina Agricultural Experiment Station, Raleigh, North Carolina. Published with the approval of the Director of Research as Paper no. 1524 of the Journal Series. This study was supported in part with a grant from The University of North Carolina at Greensboro Research Council. Part of the data was presented at the 47th Annual Meeting of the American Institute of Nutrition, Atlantic City, New Jersey, 1963.

Manuscript received 18 July 1963.





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