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Journal of Nutrition Vol. 82 No. 2 February 1964, pp. 206-208
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Free Amino Acids in Plasma and Tissues of Rats Fed a Vitamin B6-deficient Diet1

Marian E. Swendseid, Juanita Villalobos and Barbara Friedrich

School of Public Health, University of California, Los Angeles, California

Amino acids were determined in plasma, muscle and liver tissue of rats receiving vitamin B6-deficient or control diets. In the vitamin B6-deficient animals, there was a pronounced increase in the glycine-to-serine ratio, an increase in cystathionine, and an increase in aspartic acid accompanied by a decrease in alanine. The changes in plasma amino acids were accentuated by a dietary supplement of glycine.

1 Supported by a National Institutes of Health grant A-1347.

Manuscript received 9 September 1963.




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