Journal of Nutrition

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Journal of Nutrition Vol. 82 No. 2 February 1964, pp. 173-182
Copyright © 1964 by American Society for Nutrition
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Hypertension and Cardiovascular Abnormalities in Starved-Refed Swine1

G. S. Smith, Jack L. Smith2, M. S. Mameesh3, J. Simon and B. Connor Johnson

Department of Animal Science and Department of Veterinary Pathology, University of Illinois, Urbana, Illinois

Heart rate and blood pressure were recorded daily in 2 groups of young adult swine during many months of experimentation involving repeated episodes of starvation (total feed deprivation) and refeeding. Electrocardiograms from the standard and augmented limb leads were recorded during various phases of the study. Severe stresses upon the cardiovascular system were produced as a result of unrestricted initial refeeding particularly, with glucose alone or with a diet high in glucose. Damage of apparently irreversible nature was produced in the myocardium, arteries, and arterioles as a result of the stresses in refeeding following starvation. Notable diastolic hypertension was evident after only 2 starvation-refeeding episodes, and persisted following the fourth episode until the animals were killed 4 to 6 months later.

1 This investigation was supported to a large extent by the United States Air Force under Contract no. AF 41 (657) 130 and AF 41 (657)359, monitored by the Arctic Aeromedical Space Laboratory. This is not an official publication under the contract. Views or opinions expressed or implied herein are not to be construed as necessarily reflecting the views or indorsement of the Department of Air Force or of the Arctic Aeromedical Space Laboratory. Request for reprints should be addressed to: Professor B. Connor Johnson, Department of Animal Science, University of Illinois, Urbana, Illinois. The initial planning and preliminary observations in this area by Dr. Vincent Fiorica are acknowledged.

2 Post-doctoral USPHS-Trainee on NIH Research Training Grant (2G-653).

3 Present address: National Research Center, Nutrition Research Unit, Sh. el-Tahrir, Dokki, Cairo, Egypt.

Manuscript received 19 August 1963.


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