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Absorption of Preformed Vitamin A from Ligatured Poultry Intestinal Sections^1,2,

Kansas State University, Manhattan, Kansas

Absorption of aqueous dispersions of vitamin A was studied, using ligatured intestinal sections as modified in vivo systems. After injecting vitamin A acetate into duodenum, posterior small intestine, or cecum, the vitamin A content of duodenal and intestinal tissues was found to be similar, but that in blood serum was 50% higher after duodenal injections; little vitamin A was absorbed from the cecum. Absorption was better in younger and egg-strain birds than in older and broiler-strain birds. Vitamin A acetate was absorbed faster from the duodenum than from the small intestine, and also resulted in vitamin A increasing to higher levels in blood serum and liver. Vitamin A acetate was absorbed faster than the palmitate and led to higher blood serum and liver vitamin A levels. About 90% of the vitamin A in intestinal tissues was in the ester form, mainly higher fatty acid types, and about 65% of that in blood serum was in the alcohol form, whether vitamin A acetate, palmitate, or alcohol was injected. When serum vitamin A levels reached 11 µg/100 ml from single injections of vitamin A, small, but measurable, quantities of vitamin A were observed in liver. Results of simultaneous injections of ethoxyquin and vitamin A varied. Mechanisms of absorption are discussed.

² Portion of a dissertation presented by the senior author as partial fulfillment of requirements for the Ph.D. degree. For a more extensive treatment and data not presented see University Microfilms, Inc., Ann Arbor, Michigan, no. 61-1002.

³ Present address: Stanford Research Institute, Menlo Park, California.

Manuscript received 1 August 1963.