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Influence of Nicotinic, Picolinic and Pyridine-3-sulfonic Acids on Cholesterol Metabolism in the Rat¹

The Wistar Institute, Philadelphia, Pennsylvania

The addition of 1% of nicotinic, picolinic or pyridine-3-sulfonic acid to a cholesterol-free rat diet for 3 weeks did not affect serum cholesterol levels. Liver cholesterol levels of the nicotinic acid-fed rats were lower than those of the controls. When these compounds were fed at 1% of the diet to rats also receiving 2% cholesterol and 0.5% cholic acid, all test groups displayed elevated serum cholesterol levels and the nicotinic acid group also had a higher liver cholesterol content than did the controls. Hepatic cholesterogenesis from sodium acetate-1-C¹⁴ in rats fed 1% nicotinic acid or pyridine-3-sulfonic acid was significantly reduced, whereas that of the group fed picolinic acid was below that of the control group but not significantly so.

Manuscript received 19 August 1963.