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Pantothenic Acid Deficiency in Cats1

S. N. Gershoff and L. S. Gottlieb

Department of Nutrition, Harvard School of Public Health, the Mallory Institute of Pathology, Boston City Hospital, and Tufts University School of Medicine, Boston, Massachusetts

Cats were fed purified diets containing varying levels of calcium pantothenate. In pantothenic acid-deficient cats the most prominent changes were growth failure and histologic changes in the small intestines and the liver. The results of gross and histologic examinations, measurements of acetylation of urinary p-aminobenzoic and the ratio of urinary pantothenic acid to creatinine indicate that in this study, cats required approximately 5 mg of calcium pantothenate/kg of diet.

1 Supported in part by grants-in-aid from the Nutrition Foundation and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, and by Public Health Service Research Grant AM-04165 (National Institute of Arthritis and Metabolic Diseases).

Manuscript received 11 July 1963.




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