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Effect of Calcium, Phosphorus and Manganese on the Intestinal Synthesis of Thiamine in Rats

University Department of Biochemistry, Amravati Road, Nagpur, India

When rats were fed thiamine-inadequate diets containing different levels of calcium and phosphorus with or without manganese, the urinary and fecal excretion of thiamine increased in rats receiving a low level of calcium and phosphorus and supplementation of manganese to this diet resulted in more urinary and fecal thiamine excretion. Higher levels of calcium and phosphorus in the diets, with or without manganese, and diets without an added amount of these minerals decreased the urinary and fecal excretion of thiamine. The presence of manganese in the diets reduced the lactobacilli count in the cecum and increased the coliform count. Rats receiving low calcium and phosphorus diets with or without manganese stored more thiamine in the liver and cecum than did other groups, whereas no increase was noted in the thiamine content of the heart. This observation indicates that low dietary calcium and phosphorus, with or without manganese, enhanced thiamine synthesis by the intestinal flora. This thiamine might be ultimately available to rats after coprophagy.