QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chow, B. F. Articles by Lee, C.-J. Search for Related Content PubMed PubMed Citation Articles by Chow, B. F. Articles by Lee, C.-J.

Effect of Dietary Restriction of Pregnant Rats on Body Weight Gain of the Offspring¹

Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland

The effect of dietary restriction on various parameters of nutriture has been reported by a number of investigators. In all these studies, the restriction was imposed at various ages after birth. Our present study utilizes the method of dietary restriction but differs from others in that the restriction was imposed on the mother during either the gestation or lactation periods, or both. Its effect on the body weight gain and other characteristics of the offspring are reported. Restriction during gestation and lactation of the dietary intake of the rats by as little as 25% of that consumed by the unrestricted group, resulted in growth stunting of the progenies, anemia and a decreased resistance to hypothermia. Similar effects were observed when the dietary restriction was imposed during the period of gestation only. These adverse effects could be corrected by pituitary extract or growth hormone when the hormone was administered shortly after weaning, but not 3 months after birth.

Manuscript received 5 August 1963.

This article has been cited by other articles:

				A. Jones and M. Friedman Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy Science, March 19, 1982; 215(4539): 1518 - 1519. [Abstract] [PDF]

				L. Menaker and J. M. Navia Effect of Undernutrition During the Perinatal Period on Caries Development in the Rat: IV. Effects of Differential Tooth Eruption and Exposure to a Cariogenic Diet on Subsequent Dental Caries Incidence Journal of Dental Research, July 1, 1973; 52(4): 692 - 697. [Abstract] [PDF]

				S. Zamenof, E. van Marthens, and L. Grauel Prenatal Cerebral Development: Effect of Restricted Diet, Reversal by Growth Hormone Science, November 26, 1971; 174(4012): 954 - 955. [Abstract] [PDF]

				J.M. Navia, L.P. Di Orio, L. Menaker, and S. Miller Effect of Undernutrition During the Perinatal Period on Caries Development in the Rat Journal of Dental Research, May 1, 1970; 49(5): 1091 - 1098. [Abstract] [PDF]

				J. H. Shaw Marginal Protein Deficiency During the Reproductive Cycle in Rats: Influence on Body Weight and Development of Skulls and Teeth of Offspring Journal of Dental Research, February 1, 1970; 49(2): 350 - 358. [PDF]