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Journal of Nutrition Vol. 81 No. 4 December 1963, pp. 415-418
Copyright © 1963 by American Society for Nutrition
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Interrelationships of Ascorbic Acid and Pantothenic Acid in the Young Guinea Pig1

Cecelia Pudelkewicz2 and Charlotte Roderuck

Nutrition Laboratory, Iowa Agricultural and Home Economics Experiment Station, Iowa State University, Ames, Iowa

Two- to four-day-old male guinea pigs, weighing from 68 to 112 g, were fed a semi-synthetic ration along with 4 levels of ascorbic acid: 0, 2, 10, and 40 mg/day and 4 levels of calcium pantothenate: 0, 0.06, 0.2 and 1 or 8 mg/day to observe whether an interrelationship existed between the 2 vitamins in the guinea pig. Ascorbic acid in blood serum and adrenal glands reflected dietary intake of this vitamin. Hemoglobin and packed red blood cell volume increased slightly with a dietary increase of each vitamin. Pantothenic acid in the urine reflected intake of this vitamin. When calcium pantothenate was included in the diet, blood and liver values were higher than when it was omitted. Blood pyruvic acid was not correlated with concentration of pantothenic acid in blood or diet. Acute pantothenic acid deficiency symptoms included soft wooly fur, lethargy, diarrhea, convulsions and hemorrhagic adrenals. Large amounts of calcium pantothenate did not prevent symptoms of scurvy, and large amounts of ascorbic acid were not beneficial in pantothenic acid deficiency; neither did large amounts of either of the 2 vitamins have any effect on weight gain, food intake or efficiency of food utilization when compared with the smallest amounts given in these experiments.

1 Journal Paper no. J-3925 of the Iowa Agricultural and Home Economics Experiment Station, Ames, Iowa, Project no. 1213.

2 Present address: School of Home Economics, University of Missouri, Columbia.

Manuscript received 3 July 1963.




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