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Action of Vitamin a on Liver Homogenate Oxidation of Tricarboxylic Acid Cycle Intermediates¹

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

Vitamin A deficiency in young male albino rats results in a markedly elevated rate of oxidation of pyruvate, citrate, -ketoglutarate, succinate, glutamate and fumarate, but not ß-hydroxybutyrate and caprylate by liver homogenates. This effect was not observed with kidney or heart preparations and it was not due to reduced food consumption. The administration of vitamin A to deficient animals reduced the oxidation rates to normal values within 48 hours.

We gratefully acknowledge the Wisconsin Alumni Research Foundation for financial support, Merck, Sharp and Dohme for a supply of crystalline vitamins, and Professor Harry Steenbock for his valuable consultations.

² National Science Foundation Fellow.

Manuscript received 8 July 1963.