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Journal of Nutrition Vol. 81 No. 1 September 1963, pp. 67-74
Copyright © 1963 by American Society for Nutrition
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Effect of Linolenic Acid Upon the Metabolism of Linoleic Acid1

Hans Mohrhauer2 and Ralph T. Holman

University of Minnesota, The Hormel Institute, Austin, Minnesota

Weanling rats were fed a fat-free diet supplemented with highly purified linoleate and linolenate combined in several ratios. The fatty acid composition of lipids of liver, heart and adipose tissue was analyzed by gas chromatography. Increasing amounts of dietary linolenate suppressed the levels of arachidonate in tissue lipids, thus showing that the conversion of linoleate to arachidonate is inhibited by dietary linolenate.

1 Supported in part by grants from the National Institutes of Health (AMO4524-03), the Life Insurance Medical Research Fund, and the National Dairy Council.

2 Present address: Bundesministerium für wissenschaftliche Forschung, Bad Godesberg, Germany.

Manuscript received 15 February 1963.


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