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Effect of Diet on the Uptake of Carbon-14-labeled Acetate, Glucose and Leucine into Lipids of the Chick^1,2,

Poultry Department, University of Georgia, Athens, Georgia

Two trials were conducted in which chicks were fed to 2 weeks of age the following diets: (1) low protein, low fat; (2) high protein, low fat: (3) low protein plus 8% of corn oil; (4) high protein plus 8% of corn oil. These trials were conducted to compare the synthesis of lipids in the liver from acetate, glucose and leucine, and to study the effect of dietary protein and fat on the incorporation of acetate and leucine into lipids of the liver, plasma and adipose tissue. Increasing the level of dietary protein and adding corn oil to the diet each decreased the uptake of C¹⁴-labeled acetate and glucose into liver lipids. The uptake of L-leucine-2-C¹⁴ activity into liver lipids was decreased by adding corn oil to the diet, with the greatest decrease occurring at a low level of diet protein. This apparent "sparing" of protein was related to the growth response of chicks to corn oil at different protein levels. It was concluded from these studies that a high level of protein and fat is necessary in the diet of chicks to maintain a low level of liver and plasma lipids, and to obtain a rapid transport and deposition of lipids in storage sites in the body of the chick.

² This investigation was supported in part by a Public Health Service research grant no. 6338 and a research career program award no. 18,411 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health.

³ Present address: Department of Food Processing, Georgia Experiment Station, Experiment, Georgia.

Manuscript received 6 March 1963.