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Adaptation of Rats to Diets Containing Ethionine or Excess Leucine¹

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

Rats fed a diet containing a sublethal level of ethionine lose weight initially, then adapt to the diet after 6 or 7 days and grow at a rate comparable to that of the control group for at least 3 weeks. Rats fed a high leucine diet also adapt to the diet after 6 or 7 days, but the rate of growth after adaptation is below that of the ethionine-fed group, although the initial weight loss is less. The growth-retarding effects of ethionine and excess leucine were additive. Rats that had become adapted to the high leucine diet lost their ability to grow rapidly with this diet when they were fed the control diet for only one day. Rats that had become adapted to the diet containing ethionine retained their ability to grow rapidly with this diet when they were fed the control diet for as long as 3 days, but lost it when they were fed the control diet for 5 days.

² Present address: The Institute for Cancer Research, Philadelphia, Pennsylvania.

³ Present address: Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 39, Massachusetts.

Manuscript received 12 January 1963.