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Serum and Liver Protein Metabolism in Protein-depleted Dogs^{1, 2,}

Bureau of Biological Research, Rutgers, The State University, New Brunswick, New Jersey

Protein-depletion in the dog results in a decrease in liver protein and ribonucleic acid which could be correlated with body nitrogen loss. The drop in liver protein concentration may be the result of a decreased synthesis and concentration of soluble cytoplasmic and nuclear proteins. Analyses of blood serum suggested that as the dog lost body nitrogen, there was a decrease in the concentration and synthesis of serum albumin and beta globulin. In the protein-depleted dog there was evidence, also, for an increase in the relative half-life of all serum protein fractions, which did not appear to be correlated with the rates of synthesis of the various fractions. By using the current concepts of protein synthesis, it is possible to explain some of these changes in serum and liver protein in the protein-depleted dogs through an amino acid-ribonucleic acid-ribonuclease interaction.

² The work with radioactive material was performed in the Ruth Estrin Goldberg Memorial Isotope Laboratories.

Manuscript received 13 February 1963.