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Journal of Nutrition Vol. 80 No. 3 July 1963, pp. 263-269
Copyright © 1963 by American Society for Nutrition
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Response of Thyroid Hormone-deficient Rats to a Growth Factor in Duodenal Tissue1

C. J. Ackerman and V. Mah

Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg, Virginia

A procedure for preparing a water-soluble fraction of duodenal tissue is described. This fraction was administered in the drinking water to growth-arrested thyroidectomized and hypophysectomized rats, and its effect was compared with 3,5,3'-triiodo-L-thyronine. Both substances evoked comparable growth responses in these rats, but exerted different effects on certain body tissues. In addition, the duodenal fraction did not prevent goiter in the usual goiter prevention assay. When administered intraperitoneally to thyroidectomized, hypophysectomized or thiouracilfed rats, it had no effect on growth, but it reinstated growth of sulfaguanidine-fed rats whether it was administered orally or parenterally. When the duodenal fraction was digested with pancreatin and then administered to growth-arrested thiouracil-fed rats, a growth response was observed. The data from these experiments suggest that an unknown substance is present in duodenal tissue which is capable of eliciting a growth response in thyroid hormone-deficient rats.

1 Supported in part by a grant from the Williams-Waterman Fund of the Research Corporation, New York.

Manuscript received 14 January 1963.




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