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Journal of Nutrition Vol. 8 No. 1 July 1934, pp. 57-67
Copyright © 1934 by American Society for Nutrition
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Variations in the Potency of Certain Foodstuffs in the Cure of Dermatitis Induced in Rats by Dietary Egg White1

Helen T. Parsons, Jane G. Lease and Eunice Kelly

Department of Home Economics, University of Wisconsin, Madison

Cooked pork kidney is the richest source investigated, of the factor or factors which cure or prevent the dermatitis due to egg white, as it is necessary to include only one-sixth of the weight of the egg white present in a ration, for a cure. Cooked beef liver, pork liver and beef kidney are good sources, being effective if present in the ration in a concentration about onefourth that of the egg white. One to three times the weight of the egg white, of dried yeast, dried egg yolk, wheat embryo or dried milk must be incorporated to be curative. There is relatively little or no potency in spleen, heart, ovary, adrenal, blood or hemoglobin. The activity resides in the solid liver residue left from the preparation of Eli Lilly & Co. liver extract no. 343, not in the extract itself. The potency of liver does not depend on its nucleoprotein fraction.

Cooking increases the activity of raw liver or kidney; autolysis or extensive bacterial action does not decrease it. Prolonged heating, i.e., 6 days at 100°C. is destructive, especially if the material is dry. Boiling with hydrochloric acid for 1 hour at 5 or more per cent decreases the potency appreciably.

A low hemoglobin concentration is not a feature of the syndrome due to dietary egg white.

The injurious action of egg white apparently does not depend on the destruction of some dietary factor within the ration mixture.

1 This work was aided in part by a grant from the University of Wisconsin Research Fund. A preliminary report of a part of this investigation was presented to the American Society of Biological Chemists at Cincinnati, April 11, 1933 (Parsons, H. T., J. G. Lease and E. Kelly, 1933, J. Biol. Chem., vol. 100, p. lxxvii; Proc. Am. Soc. Biol. Chem., 1933, vol. 8, p. lxxvii). Published with the permission of the Director of the Wisconsin Agricultural Experiment Station.

Manuscript received 9 November 1933.




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