QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Morris, M. L. Articles by McNutt, S. H. Search for Related Content PubMed Articles by Morris, M. L., Jr. Articles by McNutt, S. H.

Influence of Lactose and Dried Skim Milk upon the Magnesium Deficiency Syndrome in the Dog

II. Pathological Changes¹

Departments of Veterinary Science and Biochemistry, University of Wisconsin, Madison, Wisconsin

In the dog low magnesium diets cause widespread calcification of the kidney, heart, blood vessels, larynx, trachea, lungs and smooth muscle of the stomach and uterus and degeneration of skeletal muscles. Dogs consuming diets marginally deficient in magnesium exhibited degenerative changes in the blood vessels. The addition of dried skim milk or MgSO₄ to the diet completely prevented the development of magnesium deficiency. Special stains indicated that magnesium may exert an effect on the integrity of mucopolysaccharides in the body. The relationship between morphological changes produced and the level of dietary magnesium was discussed. Results indicated that the calcification observed in magnesium deficiency in the dog may be a form of dystrophic calcification.

² Present address: Department of Animal Science, Purdue University, Lafayette, Indiana.

Manuscript received 29 October 1962.