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Fluoridated Water and the Skeletal Uptake of Sr⁸⁵ and Ca⁴⁵ by Young Rats¹

Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York

This investigation dealt with the effect of various levels of fluoride in the drinking water upon the accumulation of Sr⁸⁵ and Ca⁴⁵ in the skeleton of young rats. The results showed that fluoride at 1 ppm in the water had no effect upon the retention of Sr⁸⁵ and Ca⁴⁵ in the skeleton of the rats. A level of 100 ppm F^- in the water, which increased the total fluoride intake by a factor of about 10, would be expected to increase the bone concentration of ingested radiostrontium by about 30% in rats under the conditions of this study.

² On leave. Present address: Medical Research Branch, Division of Biology and Medicine, U. S. Atomic Energy Commission, Washington 25, D. C.

Manuscript received 26 September 1962.