Journal of Nutrition

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Journal of Nutrition Vol. 79 No. 2 February 1963, pp. 161-167
Copyright © 1963 by American Society for Nutrition
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Effect of Pyridoxine Deficiency upon Delayed Hypersensitivity in Guinea Pigs1

A. E. Axelrod, Anthony C. Trakatellis, Hubert Bloch2 and Warren R. Stinebring

Biochemistry and Microbiology Departments, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Pyridoxine-deficient guinea pigs inoculated with Mycobacterium tuberculosis, BCG exhibited depressed delayed-hypersensitivity skin reactions to the allergen, purified protein derivative (PPD). Deoxypyridoxine treatment of previously sensitized animals also depressed skin reactivity. However, in vitro tests and passive transfer experiments demonstrated that cells of the pyridoxine-deficient animals were sensitive to PPD. Altered skin sensitivity may be explained not by a lack of cellular sensitivity, skin tissue changes, or inanition but by a depressed ability of sensitized cells to react with PPD.

1 This investigation was supported in part by PHS grants A-727 from the National Institute of Arthritis and Metabolic Diseases and E-2104 from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.

2 Present address: Ciba Laboratories, Basel, Switzerland.

Manuscript received 10 September 1962.




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