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Vitamin E Deficiency in the Monkey

V. Estimated Requirements and the Influence of Fat Deficiency and Antioxidants on the Syndrome¹

Department of Biochemistry, School of Medicine, University of Arkansas, Little Rock, Arkansas

The influence of a fat-deficient diet and N,N'-diphenyl-p-phenylenediamine (DPPD) on vitamin E deficiency was studied in the rhesus monkey. Fat deficiency did not prevent the monkeys from developing the full syndrome of vitamin E deficiency including the anemia, but it appeared to reduce the requirement for vitamin E. The estimated requirement for monkeys receiving the diet containing fat was 2 to 3 mg of DL--tocopherol per kg body weight per day, whereas a single estimate of the requirement in a monkey supplied with the fat-deficient diet was 0.7 mg per kg of body weight per day. Also the average length of time required to develop vitamin E deficiency was longer in the fat-deficient monkeys. The DPPD had a beneficial effect in the vitamin E-deficient monkeys but the response was not complete.

Several electrocardiograms were obtained for each of the monkeys in these experiments and a relatively high incidence of abnormalities due to pericarditis was noted. No abnormalities were present in the electrocardiograms that could be attributed either to vitamin E deficiency or fat deficiency.

² Studies carried out during the tenure of a National Vitamin Foundation—Russell M. Wilder Fellowship.

Manuscript received 4 September 1962.