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Body Iron Levels and Hematologic Findings during Excess Methionine Feeding¹

Department of Pathology, Duke University Medical Center, Durham, North Carolina

Since it is known that ethionine causes an increase in iron absorption and that excessive amounts of methionine in the diet will produce similar histologic changes in the pancreas, gastrointestinal tract, and salivary glands, experiments were devised whereby rats were fed diets containing 2% of DL-methionine for one month. There was no increase in iron absorption under this regimen. The rats receiving excess methionine developed a microcytic hypochromic anemia, erythroid hyperplasia of the bone marrow and an increase in the peripheral white blood cell count.

Manuscript received 9 August 1962.

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