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The Nature of the Antithyrotoxic Effect of Liver Residue¹

Department of Biochemistry, State University of New York, Upstate Medical Center, Syracuse, New York

1. Liver residue counteracted the metabolic effects of iodinated casein in proportion to the relative amounts of the two substances in the diet, but did not restore the metabolic rate completely nor decrease the endogenous metabolic rate.

2. Growth and survival simply reflected the magnitude of the effect of liver residue in reducing the metabolic rate; with large amounts of liver residue some other limitations on growth occured before the maximal reduction in metabolic rate was achieved.

3. Liver residue counteracted the metabolic effects of dietary thyroxine, triiodothyronine, triiodothyroacetic acid, tetraiodothyroacetic acid and triiodothyropropionic acid, but was less effective against diiodothyroacetic acid. It also counteracted subcutaneous thyroxine, but less effectively than dietary thyroxine. The range of concentration of triiodothyronine within which an effect of liver residue could be demonstrated was very narrow.

4. The high metabolic rate produced by prefeeding iodinated casein was restored to normal more rapidly when the diet contained liver residue or cholic acid.

Manuscript received 6 August 1962.