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Effect of Nonessential Nitrogen Supplements on Growth and on the Amino Acid Content in Plasma and Muscle of Weanling Rats Fed a Low-Protein Diet¹

School of Public Health, and Department of Physiological Chemistry, School of Medicine, University of California, Los Angeles, California

Various nonessential nitrogen supplements including glycine, glutamic acid, a mixture of glutamic acid and diammonium citrate and a mixture of the nonessential amino acids proportioned as in casein were found to retard the growth of young rats when they were added to diets containing 8.0% of casein and 0.3% of methionine. The effect can be prevented by additions of threonine and tryptophan except in the case of the 7.5% glycine supplement. Increases in the nonessential amino acids fed as supplements and their metabolic derivatives were found in the plasma and muscle tissue. In some instances, the essential amino acids appeared to be decreased. On an isonitrogenous basis, glycine supplementation caused the greatest reduction in growth rate and produced the greatest changes in plasma amino acid concentrations.

² Part of the data are taken from a thesis submitted by Janice B. Hickson to the Graduate School, U.C.L.A. in partial fulfillment of the requirements for the degree of Master of Science.

Manuscript received 2 March 1962.