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Journal of Nutrition Vol. 78 No. 1 September 1962, pp. 109-114
Copyright © 1962 by American Society for Nutrition
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Effect of Vitamin B12 Deficiency on Cholesterol Metabolism

Elena E. Icayan1 and Bacon F. Chow

The Johns Hopkins University, School of Hygiene and Public Health, Department of Biochemistry, Baltimore, Maryland

The role of vitamin B12 in cholesterol metabolism was investigated. It was demonstrated that vitamin B12 deficiency results in (a) low levels of total cholesterol in the serum and the liver of male rats, but not in female rats; (b) an increase in the percentage of incorporation of C14 acetate into cholesterol in liver which was reversed by vitamin B12 administration; and (c) a higher specific activity of cholesterol in the liver after administration of tracer acetate. It was demonstrated further that the oxidation of acetate is not impaired.

1 Present address: University of the East, Ramon Magsaysay Memorial Medical Center, Aurora Boulevard, Quezon City, Philippines. ICA-NEC-UERMMMC Fellow.

Manuscript received 6 April 1962.




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