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Journal of Nutrition Vol. 77 No. 3 July 1962, pp. 332-342
Copyright © 1962 by American Society for Nutrition
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Studies on the Physiological Functions of Thiamine

II. Effects of Sorbitol on Growth and {alpha}-Ketoacid Metabolism in Thiamine-Deficient and Antagonist-Treated Rats1

C. J. Gubler2 and G. Eleanor Bethsold3

Department of Chemistry, Brigham Young University, Provo, Utah

Rats made deficient by thiamine deprivation or by injections of the thiamine antagonists oxythiamine and pyrithiamine were divided into two groups, one being fed a basal diet and the other this diet containing 20% of sorbitol, in order to study the effects of sorbitol on growth and on {alpha}-keto acid metabolism in the three types of thiamine deficiency. In all cases where the deficiency caused a decrease in the growth or the oxidative decarboxylation of pyruvate or {alpha}-ketoglutarate in the tissues, the feeding of 20% of sorbitol in the diet reversed this effect and resulted in essentially normal levels in the tissues. On the other hand, the elevations in blood pyruvate associated with thiamine deprivation and OTh treatment were not decreased to normal by sorbitol feeding. The PTh treatment failed to affect the blood pyruvate either with or without sorbitol. The changes in total {alpha}-keto acids in blood paralleled those for pyruvate and were largely due to the changes in pyruvate.

1 This investigation was supported by: (1) a research grant (A-2448) from the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service, and (2) an Advanced Research Fellowship, American Heart Association 1958–60.

2 Established Investigator, American Heart Association.

3 Part of this work was done in partial fulfillment of the requirements for the degree of Master of Science. Present address: Carnation Research Laboratories, 8015 Van Nuys Boulevard, Van Nuys, California.

Manuscript received 9 December 1961.




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