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Journal of Nutrition Vol. 77 No. 3 July 1962, pp. 264-268
Copyright © 1962 by American Society for Nutrition
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Sheep Erythrocyte Life Span in Estimation of Hemoglobin Turnover in Iron Metabolism Studies1

Joseph T. Judd and G. Matrone2

Animal Nutrition Section of the Department of Animal Industry, North Carolina State College, Raleigh, North Carolina

Estimates of the life span of the erythrocytes of three sheep were made using methylene-labeled C14 glycine. The results obtained showed life spans of 131, 157, and 150 days which exceeded by approximately threefold previous estimates in which indirect techniques were used. The effect of the magnitude of erythrocyte life span on iron metabolism studies involving estimation of "physiological iron requirement" for maintenance is discussed.

1 Contribution from the Animal Industry Department, North Carolina Agricultural Experiment Station, Raleigh, North Carolina. Published with the approval of the Director of Research as Paper no. 1123 of the Journal Series.

2 Supported in part by a grant from the Herman Frasch Foundation.

Manuscript received 26 February 1962.




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