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Journal of Nutrition Vol. 76 No. 4 April 1962, pp. 460-466
Copyright © 1962 by American Society for Nutrition
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Effects of Dietary Fat on Cholesterol Metabolism in the Diabetic Rat1

Paul T. Russell, Jean C. Scott and John T. Van Bruggen

Department of Biochemistry, University of Oregon Medical School, Portland, Oregon

1. The effects of corn oil and lard diets upon blood and tissue cholesterol in normal and alloxan diabetic rats are reported and discussed.
2. Dietary lard aggravated a trend towards hypercholesterolemia in the alloxan diabetic rat.
3. The corn oil diet increased the amount of sterol found in the livers of both the diabetic and normal animals.
4. Lard feeding increased the sterol content of the livers of normal animals as well as diabetic animals, but the increase was not as pronounced as with corn oil feeding.
5. Gut, carcass and skin data were presented and discussed.
6. The feeding of 10 or 30% of corn oil or lard diets to diabetic or normal animals resulted in no change in cholesterologenesis using mevalonic acid-2-C14 as the cholesterol precursor.

1 This investigation was supported largely by Contract no. AT (45-1)-225 of the United States Atomic Energy Commission. These data are in part from a thesis submitted by Paul Russell to the University of Oregon Medical School in partial fulfillment of the requirement for the degree of Master of Science.

Manuscript received 27 October 1961.




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