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Tissue Cholesterol Ester and Triglyceride Fatty Acid Composition of Rabbits Fed Cholesterol Diets High and Low in Linoleic Acid¹

Veterans Administration Center, Martinsburg, West Virginia and Department of Biochemistry, School of Medicine, The George Washington University, Washington, D. C.

The observations indicate that the nature of the dietary fat incorporated into a high-cholesterol diet influences the serum and tissue cholesterol ester and triglyceride fatty acid composition. The aorta cholesterol esters are not of constant composition, but are dependent upon the fatty acid composition of the dietary fat fed. The data also suggest that derangements of cholesterol oleate metabolism may be an important factor involved in the deposition of cholesterol esters in liver and aorta of rabbits fed high-cholesterol diets.

Manuscript received 26 October 1961.