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Department of Biochemistry, University of Wisconsin, Madison, Wisconsin
The minimal magnesium requirement of the weanling dog fed a semipurified diet was found to be approximately 140 ppm (dry weight basis).
Mineralized lesions were observed in the thoracic aorta of the animals fed the low magnesium. Upon analysis, the mineral was observed to consist largely of calcium and phosphorus. The amount of mineral accumulation in the aorta appeared to be a function of the magnesium content and duration of intake of the diet.
An elevation of blood serum inorganic phosphorus and a depression of serum calcium and magnesium appeared in the lowmagnesium-fed (80 ppm) weanling dog, but no change in aortic magnesium content could be detected.
2 Present address: U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver 30, Colorado.
Manuscript received 14 July 1961.