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Pantothenic Acid Excretion on Three Levels of Intake¹

Human Nutrition Research Laboratory, Department of Home Economics, College of Agriculture, University of Nebraska, Lincoln, Nebraska

Urinary excretion of pantothenic acid was measured in response to self-chosen diets and to a controlled standardized diet providing 2.8, 7.8 and 12.8 mg of pantothenic acid daily. Each subject was studied for 10 days at each level of pantothenic acid intake following an adjustment period using the standardized diet. Excretion of pantothenic acid responded to changes in intake. The mean excretion on intakes of 2.8, 7.8 and 12.8 mg of pantothenic acid daily was 3.2, 4.5 and 5.6 mg, respectively. Comparison of the excretion of the subjects fed the higher levels of pantothenic acid in different order indicates that urinary excretion may reflect previous dietary intake of the vitamin.

The calculated pantothenic acid content of quantitatively estimated self-chosen diets that were adequate with respect to other nutrients was approximately 7 mg daily. The mean pantothenic acid excretion by subjects consuming these self-chosen diets was 3.9 mg daily.

Altering the pantothenic acid intake from 2.8 to 12.8 mg daily did not affect the excretion of other nutrients.

² Present address: School of Home Economics, University of Wisconsin, Madison, Wisconsin.

Manuscript received 22 July 1961.