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Journal of Nutrition Vol. 75 No. 4 December 1961, pp. 443-446
Copyright © 1961 by American Society for Nutrition
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Studies on the Combined and Relative Influence of Dietary Protein and Riboflavin in Flavoprotein Enzymes

S. Ramakrishnan, V. Srinivasan and T. M. B. Nedungadi

Department of Biochemistry, Madurai Medical College, Madurai, Madras State, South India

1. Xanthine oxidase and D-amino acid oxidase activities were determined in the livers of 8 groups of rats with 5, 18, 40 and 60% of devitaminized casein with and without added riboflavin.
2. Both xanthine oxidase and D-amino acid oxidase activities of rat liver were reduced to the minimum in a combined deficiency of dietary protein and riboflavin.
3. Xanthine oxidase activity depended much more upon protein (casein) than upon riboflavin, whereas D-amino acid oxidase activity depended more upon riboflavin than upon protein.

Manuscript received 23 February 1961.




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