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Journal of Nutrition Vol. 75 No. 3 November 1961, pp. 347-353
Copyright © 1961 by American Society for Nutrition
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Protective Action of Bile Acids in Experimental Thyrotoxicosis

L. R. Overby and R. L. Fredrickson

Research Division, Abbott Laboratories, North Chicago, Illinois

Deoxycholic acid protected rats from experimental thyrotoxicosis. Hyodeoxycholic acid, lithocholic acid and cholesterol were inactive. Cholic acid was slightly active. Fractions from liver, containing neither neutral lipids, bile acids nor cholesterol, also protected rats from chronic thyrotoxicosis. The maximum response from deoxycholic acid was about 60% of the maximum obtained with liver fractions. The combination of deoxycholic acid and liver gave almost complete protection. The substances were active with oral or injected thyroxine, and in rats with chemotherapeutically-sterilized intestinal tracts.

Manuscript received 5 June 1961.




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